ED Pathway

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ED Pathway: 

Introduction:

1) ED pathway was discovered by two scientists name Nathan Entner and Michael Duodorof.

2) It is the alternative pathway of glycolysis in which glucose is converted into pyruvate.

3) This pathway is present in prokaryotes in cytoplasm. 

4) This pathway contains most of the gram-negative bacteria and some of gram-positive bacteria.

5) This pathway is first identified in pseudomonas saccharophila.

6) It contains two specific enzymes one is phosphogluconate and other is KDPG.

7) This pathway generates one ATP, one NAD and one NADPH.

8) ED pathways contain relatively low energy which contain most of their energy through oxidative phosphorylation. 

9) In fermented bacterium like Zymomonas mobilis uses ED pathway under anaerobic conditions.

10) ED pathway is one of the pathways that is used by microorganisms by the wide variety of carbon-energy sources depending upon the organisms and growth conditions.

11) It occurs in both aerobic and anaerobic conditions.

Steps of ED Pathway:

Steps of ED pathway is just like same as that of  glycolysis.

Step 1:

In the first step glucose is phosphorylated by using ATP in the presence of Hexokinase enzyme and generate glucose 6-phosphate. 

Step 2:  

Glucose 6-phosphate is then oxidized into 6-phosphogluconate by releasing of NADPH, this reaction is catalyzed by the enzyme glucose 6-phosphate dehydrogenase enzyme.

Step 3:

In the next step 6-phosphoglucolactone is converted into 6-phosphogluconate by the enzyme hydrolase.

 Step 4:  

In the next step in which 6-phosphogluconate contain dehydration reaction in which is catalyzed by the enzyme 6-phosphogluconate dehydratase to form 2-keto-3-deoxy-6-phosphogluconate (KDPG).

Step 5:   

In this step in which KDPG spilt to form pyruvate and glyceraldehyde 3-phosphate.

Step 6:

In the last step in which glyceraldehyde 3-phosphate is then metabolized by glycolysis to form pyruvate. 

Flowchart:


ED Pathway



 Significance of ED Pathway:

1) It contain two specific enzymes one is phosphogluconate and other is KDPG.

2) It generates one ATP, one NAD and one NADPH molecule.

3) Its role is important in sugar catabolism of many organisms.

Importance:

1) ED pathway is the intermediate of 6- gluconate and serve as a starting point.

2) ED pathway plays important role in sugar catabolism.

3) ED is important because it regulates the pathway.

My name is Ehsan and Iam from Pakistan and studding bs microbiology in 5th semester student

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